02196nam a22003377a 4500003000800000005001700008008004100025020004300066020004100109040004100150050002400191100003800215245010000253246005100353250001200404260000600416264004100422300002200463336002600485337003300511338002900544504005100573505106900624650002201693650002301715650002201738650002201760650002301782700003101805700002201836IQ-NaUA20221101064410.0110512s2012    nyu      b    001 0 eng    a9780071603935 (hardcover : alk. paper)  a 007160393X (hardcover : alk. paper)  aIQ-NaUAbaracIQ-NaUAdIQ-KaLSSerda 4a RM301.4b.S52 20121 aShargel, Leon, d 1941-eauthor. 10aApplied biopharmaceutics & pharmacokinetics / b Leon Shargel, Andrew B.C. Yu, Susanna Wu-Pong.1 a Applied biopharmaceutics and pharmacokinetics  a6th ed.  a  1aNew York : bMcGraw-Hill, c2012 c.   a 782 p ;c25 cm.   2rdacontentaنصbtxt  2rdamediaaدون وسيطbn  2rdacarrieraمجلدbnc  aIncludes bibliographical references and index.0 a	 |a Introduction to biopharmaceutics and pharmacokinetics -- Mathematic fundamentals in pharmacokinetics -- One-compartment open model: intravenous bolus administration -- Multicompartmental models : intravenous bolus administration -- Intravenous infusion -- Drug elimination and clearance -- Pharmacokinetics of oral absorption -- Multiple-dosage regimens -- Nonlinear pharmacokinetics -- Physiologic drug distribution and protein binding -- Drug elimination and hepatic clearance -- Pharmacogenetics -- Physiologic factors related to drug absorption -- Biopharmaceutic considerations in drug product design and in vitro drug product performance -- Drug product performance, in vivo : bioavailability and bioequivalence -- Impact of drug product quality and biopharmaceutics on clinical efficacy -- Modified-release drug products -- Targeted drug delivery systems and biotechnology products -- Relationship between pharmacokinetics and pharmacodynamics -- Application of pharmacokinetics to clinical situations -- Dosage adjustment in renal and hepatic disease. 4aBiopharmaceutics. 4a Pharmacokinetics. 4aBiopharmaceutics. 4aModels, Chemical. 4a Pharmacokinetics.1 a Yu, Andrew B. C.,d1945- 1 aWu-Pong, Susanna.