nam a22 7a 4500 7857 7857 IQ-NaUA 20221101064410.0 110512s2012 nyu b 001 0 eng 9780071603935 (hardcover : alk. paper) 007160393X (hardcover : alk. paper) IQ-NaUA ara IQ-NaUA IQ-KaLSS rda RM301.4 .S52 2012 Shargel, Leon, 1941- author. Applied biopharmaceutics & pharmacokinetics / Leon Shargel, Andrew B.C. Yu, Susanna Wu-Pong. Applied biopharmaceutics and pharmacokinetics 6th ed. New York : McGraw-Hill, 2012 c. 782 p ; 25 cm. rdacontent نص txt rdamedia دون وسيط n rdacarrier مجلد nc Includes bibliographical references and index. |a Introduction to biopharmaceutics and pharmacokinetics -- Mathematic fundamentals in pharmacokinetics -- One-compartment open model: intravenous bolus administration -- Multicompartmental models : intravenous bolus administration -- Intravenous infusion -- Drug elimination and clearance -- Pharmacokinetics of oral absorption -- Multiple-dosage regimens -- Nonlinear pharmacokinetics -- Physiologic drug distribution and protein binding -- Drug elimination and hepatic clearance -- Pharmacogenetics -- Physiologic factors related to drug absorption -- Biopharmaceutic considerations in drug product design and in vitro drug product performance -- Drug product performance, in vivo : bioavailability and bioequivalence -- Impact of drug product quality and biopharmaceutics on clinical efficacy -- Modified-release drug products -- Targeted drug delivery systems and biotechnology products -- Relationship between pharmacokinetics and pharmacodynamics -- Application of pharmacokinetics to clinical situations -- Dosage adjustment in renal and hepatic disease. Biopharmaceutics. Pharmacokinetics. Biopharmaceutics. Models, Chemical. Pharmacokinetics. Yu, Andrew B. C., 1945- Wu-Pong, Susanna. سارة حميد المرشدي. lcc BK